The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts

Hisako Okada, Tadayoshi Kurita, Toshiaki Mochizuki, Koji Morita, Shigehito Sato

研究成果: Article査読

108 被引用数 (Scopus)

抄録

Aim: Dexmedetomidine is a highly specific and selective α-2 adrenergic agonist that is now widely used in the intensive care setting. Many intensive care unit (ICU) patients are at risk of respiratory or cardiac arrest. This study was conducted to determine whether dexmedetomidine exhibits a cardioprotective effect on global ischaemia and subsequent myocardial infarction. Methods: Isolated rat hearts were subjected to 30 min of global ischaemia followed by 120 min reperfusion, with administration of 0, 1 and 10 nM dexmedetomidine during the pre-ischaemic period (n = 7 each group). Secondly, 1 μM yohimbine, an α-2 antagonist, was given during the pre-ischaemic period, alone or in combination with 10 nM dexmedetomidine (n = 7 each group). Results: Dexmedetomidine administration reduced coronary flow significantly (103.6 ± 4.7%, 77.9 ± 3.7, 63.7 ± 6.1%, of the baseline values for 0, 1 and 10 nM dexmedetomidine, respectively), and yohimbine administration reversed this effect (88.0 ± 2.2%). Dexmedetomidine improved the infarct size at each concentration (45.3 ± 3.6, 30.2 ± 3.3, and 21.2 ± 2.3% of the total left ventricular mass for 0, 1, and 10 nM dexmedetomidine, respectively), which was also reversed by yohimbine (43.6 ± 1.4%). Conclusion: Dexmedetomidine exhibited a cardioprotective effect on global ischaemia in the isolated rat heart model, which was mediated by α-2 adrenergic stimulation.

本文言語English
ページ(範囲)538-545
ページ数8
ジャーナルResuscitation
74
3
DOI
出版ステータスPublished - 09-2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 救急医学
  • 緊急
  • 循環器および心血管医学

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