The change of creatine kinase bb isozyme in patients undergoing mitral value replacement--comparison with creatine kinase MB and MM isozymes

A. Usui, T. Abe, M. Murase, M. Tanaka, E. Takeuchi, K. Kato

研究成果: ジャーナルへの寄稿学術論文査読

抄録

By using highly sensitive enzyme immunoassay method recently developed, concentrations of the three forms of cytoplasmic creatine kinases (CK-BB, CK-MB and CK-MM) were determined in blood plasma samples serially taken from 18 patients, who received mitral valve replacement. Plasma CK-BB levels, that were 0.64 +/- 0.32 ng/ml at the beginning of anesthesia, increased sharply after reperfusion reaching peak levels (23.3 +/- 7.56 ng/ml) at 2 hours after reperfusion, and then decreased rapidly. The response of CK-BB in plasma was more rapid and sensitive than that of CK-BB or CK-MM. The CK-BB concentrations were significantly higher in coronary sinus samples than in arterial samples. These results suggest that the major portion of elevated plasma CK-BB levels at early phase after reperfusion were considered to be derived from the heart muscle.

本文言語英語
ページ(範囲)1481-1485
ページ数5
ジャーナルJournal of the Japanese Association for Thoracic Surgery
37
8
出版ステータス出版済み - 08-1989

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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