The characteristics of blood-brain barrier in three different conditions - infarction, selective neuronal death and selective loss of presynaptic terminals - following cerebral ischemia

K. Kitagawa, M. Matsumoto, T. Ohtsuki, M. Tagaya, T. Okabe, R. Hata, H. Ueda, N. Handa, K. Sobue, T. Kamada

研究成果: Article査読

16 被引用数 (Scopus)

抄録

We investigated the extravasation of serum albumin using immunohistochemistry in three different conditions, i.e., infarction, selective neuronal death and selective loss of presynaptic terminals following cerebral ischemia in gerbils. In selective neuronal death, which is typically found in the CA1 neurons of the hippocampus after 5-min bilateral cerebral ischemia, selective damage of postsynaptic components with intact presynaptic sites was demonstrated by immunohistochemical examination for microtubule-associated protein 2 and synapsin I, and albumin extravasation did not become apparent before postsynaptic structures were destroyed. In cerebral infarction, which was consistently observed in the thalamus after 15-min forebrain ischemia, massive albumin extravasation was visible early after ischemia due probably to the ischemic endothelial necrosis. In selective loss of presynaptic terminals, which was detected at the molecular layer of the dentate gyrus in the contralateral, nonischemic hippocampus after unilateral cerebral ischemia, immunoreaction for albumin was not visualized. Since endothelium and glial cells were intact in morphological aspects in selective damage of both pre- and postsynaptic sites, it was thought that extravasation was facilitated by the stimulation of endothelial cells and glial cells with unknown factors that were induced by the destruction of post- but not presynaptic elements.

本文言語English
ページ(範囲)378-386
ページ数9
ジャーナルActa Neuropathologica
84
4
DOI
出版ステータスPublished - 01-09-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 臨床神経学
  • 細胞および分子神経科学

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