TY - JOUR
T1 - The coexistence of systemic sclerosis and rheumatoid arthritis in five patients
AU - Horiki, Terumi
AU - Moriuchi, Junko
AU - Takaya, Masatoshi
AU - Uchiyama, Mitsuaki
AU - Hoshina, Yuichi
AU - Inada, Kenichi
AU - Inoko, Hidetoshi
AU - Tsuji, Kmiyoshi
AU - Ichikawa, Yukinobu
PY - 1996/1
Y1 - 1996/1
N2 - To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.
AB - To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.
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U2 - 10.1002/art.1780390121
DO - 10.1002/art.1780390121
M3 - Article
C2 - 8546724
AN - SCOPUS:0030032611
VL - 39
SP - 152
EP - 156
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 1
ER -