The coexistence of systemic sclerosis and rheumatoid arthritis in five patients

Terumi Horiki, Junko Moriuchi, Masatoshi Takaya, Mitsuaki Uchiyama, Yuichi Hoshina, Kenichi Inada, Hidetoshi Inoko, Kmiyoshi Tsuji, Yukinobu Ichikawa

研究成果: Article査読

44 被引用数 (Scopus)

抄録

To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DQB1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.

本文言語English
ページ(範囲)152-156
ページ数5
ジャーナルArthritis and Rheumatism
39
1
DOI
出版ステータスPublished - 01-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • リウマチ学
  • 免疫学
  • 薬理学(医学)

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