The critical role of germinal center-associated nuclear protein in cell biology, immunohematology, and hematolymphoid oncogenesis

Yasuhiro Sakai, Suchada Phimsen, Seiji Okada, Kazuhiko Kuwahara

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Germinal center-associated nuclear protein (GANP) is a unique and multifunctional protein that plays a critical role in cell biology, neurodegenerative disorders, immunohematology, and oncogenesis. GANP is an orthologue of Saccharomyces Sac3, one of the components of the transcription export 2 (TREX-2) complex and a messenger RNA (mRNA) nuclear export factor. GANP is widely conserved in all mammals, including humans. Although GANP was originally discovered as a molecule upregulated in the germinal centers of secondary lymphoid follicles in peripheral lymphoid organs, it is expressed ubiquitously in many tissues. It serves numerous functions, including making up part of the mammalian TREX-2 complex; mRNA nuclear export via nuclear pores; prevention of R-loop formation, genomic instability, and hyper-recombination; and B-cell affinity maturation. In this review, we first overview the extensive analyses that have revealed the basic functions of GANP and its ancestor molecule Sac3, including mRNA nuclear export and regulation of R-loop formation. We then describe how aberrant expression of GANP is significantly associated with cancer development. Moreover, we discuss a crucial role for GANP in B-cell development, especially affinity maturation in germinal centers. Finally, we illustrate that overexpression of GANP in B cells leads to lymphomagenesis resembling Hodgkin lymphoma derived from germinal center B cells, and that GANP may be involved in transdifferentiation of B cells to macrophages, which strongly affects Hodgkin lymphomagenesis.

本文言語English
ページ(範囲)30-38
ページ数9
ジャーナルExperimental Hematology
90
DOI
出版ステータスPublished - 10-2020

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 血液学
  • 遺伝学
  • 細胞生物学
  • 癌研究

フィンガープリント

「The critical role of germinal center-associated nuclear protein in cell biology, immunohematology, and hematolymphoid oncogenesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル