The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice

Hideyuki Ogiso, Hiroyasu Ito, Tatsuya Ando, Yuko Arioka, Ayumu Kanbe, Kazuki Ando, Tetsuya Ishikawa, Kuniaki Saito, Akira Hara, Hisataka Moriwaki, Masahito Shimizu, Mitsuru Seishima

研究成果: Article

6 引用 (Scopus)

抄録

In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4 -induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4 , the number of several inflammatory cells and the expression of proinflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl4 administration in IDO-KO mice compared to WT mice. Moreover, the treatment with L-tryptophan aggravated the CCl4 -induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl4 -treated mice.

元の言語English
記事番号e0162183
ジャーナルPloS one
11
発行部数9
DOI
出版物ステータスPublished - 09-2016

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Indoleamine-Pyrrole 2,3,-Dioxygenase
liver cirrhosis
Liver Cirrhosis
Liver
mice
Hepatic Stellate Cells
liver
Fibrosis
Tryptophan
cells
indoleamine 2,3-dioxygenase
Cytokines
tryptophan
cytokines
inflammation
Inflammation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

これを引用

Ogiso, H., Ito, H., Ando, T., Arioka, Y., Kanbe, A., Ando, K., ... Seishima, M. (2016). The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice. PloS one, 11(9), [e0162183]. https://doi.org/10.1371/journal.pone.0162183
Ogiso, Hideyuki ; Ito, Hiroyasu ; Ando, Tatsuya ; Arioka, Yuko ; Kanbe, Ayumu ; Ando, Kazuki ; Ishikawa, Tetsuya ; Saito, Kuniaki ; Hara, Akira ; Moriwaki, Hisataka ; Shimizu, Masahito ; Seishima, Mitsuru. / The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice. :: PloS one. 2016 ; 巻 11, 番号 9.
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abstract = "In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4 -induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4 , the number of several inflammatory cells and the expression of proinflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl4 administration in IDO-KO mice compared to WT mice. Moreover, the treatment with L-tryptophan aggravated the CCl4 -induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl4 -treated mice.",
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Ogiso, H, Ito, H, Ando, T, Arioka, Y, Kanbe, A, Ando, K, Ishikawa, T, Saito, K, Hara, A, Moriwaki, H, Shimizu, M & Seishima, M 2016, 'The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice', PloS one, 巻. 11, 番号 9, e0162183. https://doi.org/10.1371/journal.pone.0162183

The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice. / Ogiso, Hideyuki; Ito, Hiroyasu; Ando, Tatsuya; Arioka, Yuko; Kanbe, Ayumu; Ando, Kazuki; Ishikawa, Tetsuya; Saito, Kuniaki; Hara, Akira; Moriwaki, Hisataka; Shimizu, Masahito; Seishima, Mitsuru.

:: PloS one, 巻 11, 番号 9, e0162183, 09.2016.

研究成果: Article

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T1 - The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice

AU - Ogiso, Hideyuki

AU - Ito, Hiroyasu

AU - Ando, Tatsuya

AU - Arioka, Yuko

AU - Kanbe, Ayumu

AU - Ando, Kazuki

AU - Ishikawa, Tetsuya

AU - Saito, Kuniaki

AU - Hara, Akira

AU - Moriwaki, Hisataka

AU - Shimizu, Masahito

AU - Seishima, Mitsuru

PY - 2016/9

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