TY - JOUR
T1 - The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice
AU - Ogiso, Hideyuki
AU - Ito, Hiroyasu
AU - Ando, Tatsuya
AU - Arioka, Yuko
AU - Kanbe, Ayumu
AU - Ando, Kazuki
AU - Ishikawa, Tetsuya
AU - Saito, Kuniaki
AU - Hara, Akira
AU - Moriwaki, Hisataka
AU - Shimizu, Masahito
AU - Seishima, Mitsuru
N1 - Publisher Copyright:
© 2016 Ogiso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/9
Y1 - 2016/9
N2 - In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4 -induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4 , the number of several inflammatory cells and the expression of proinflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl4 administration in IDO-KO mice compared to WT mice. Moreover, the treatment with L-tryptophan aggravated the CCl4 -induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl4 -treated mice.
AB - In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4 -induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4 , the number of several inflammatory cells and the expression of proinflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl4 administration in IDO-KO mice compared to WT mice. Moreover, the treatment with L-tryptophan aggravated the CCl4 -induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl4 -treated mice.
UR - https://www.scopus.com/pages/publications/84991407945
UR - https://www.scopus.com/pages/publications/84991407945#tab=citedBy
U2 - 10.1371/journal.pone.0162183
DO - 10.1371/journal.pone.0162183
M3 - Article
C2 - 27598994
AN - SCOPUS:84991407945
SN - 1932-6203
VL - 11
JO - PloS one
JF - PloS one
IS - 9
M1 - e0162183
ER -