The different association of epicardial fat with coronary plaque in patients with acute coronary syndrome and patients with stable angina pectoris: Analysis using integrated backscatter intravascular ultrasound

Kazuhiro Harada, Ken Harada, Tadayuki Uetani, Tadashi Kataoka, Masahiro Takeshita, Ayako Kunimura, Yohei Takayama, Norihiro Shinoda, Bunichi Kato, Masataka Kato, Nobuyuki Marui, Hideki Ishii, Tatsuaki Matsubara, Tetsuya Amano, Toyoaki Murohara

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Objectives: We assessed the hypothesis that the epicardial fat is associated with coronary lipid plaque. Background: Epicardial fat volume (EFV) is increased in patients with acute coronary syndrome (ACS), and lipid-rich plaques have been associated with acute coronary events. Methods: We enrolled 112 individuals who underwent percutaneous coronary intervention (PCI) (66 with ACS; 46 with stable angina pectoris [SAP]) and classified plaque components using integrated backscatter intravascular ultrasound as calcified, fibrous, or lipid. Possible effects of PCI on plaque data were minimized by assessing 10-mm vessel lengths proximal to the culprit lesions. Total plaque volume and percentage volumes of individual plaque components were calculated. EFV and abdominal visceral fat area were measured using 64-slice computed tomography. Results: ACS patients had significantly higher EFV than did SAP patients (118 ± 44 vs.101 ± 41 mL, p = 0.019). In ACS patients, EFV was correlated with total plaque volume and percentage of lipid plaque (r = 0.27 and 0.31, respectively; p < 0.05). Moreover, an independent interaction between EFV and lipid-rich plaque (odds ratio, 1.04; 95% confidence interval, 1.00-1.07) were revealed. In contrast, in SAP patients, EFV was positively correlated with body mass index and abdominal visceral fat area but not with plaque characteristics. Conclusions: EFV was associated with lipid-rich plaque in patients with ACS, whereas no correlation between EFV and coronary plaque profile was apparent in SAP patients. Epicardial fat may have a role in the development of lipid plaque, which contributes to the pathogenesis of ACS.

本文言語English
ページ(範囲)301-306
ページ数6
ジャーナルAtherosclerosis
236
2
DOI
出版ステータスPublished - 01-10-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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