The disease sites of female genital cancers of BRCA1/2-associated hereditary breast and ovarian cancer: a retrospective study

and the Registration Committee of the Japanese HBOC consortium

研究成果: Letter査読

1 被引用数 (Scopus)

抄録

Disease sites of female genital tract cancers of BRCA1/2-associated hereditary breast and ovarian cancer (HBOC) are less understood than non-hereditary cancers. We aimed to elucidate the disease site distribution of genital cancers in women with the germline BRCA1 and BRCA2 pathogenic variants (BRCA1+ and BRCA2+) of HBOC. For the primary disease site, the proportion of fallopian tube and peritoneal cancer was significantly higher in BRCA2+ (40.5%) compared with BRCA1+ (15.4%) and BRCA− (no pathogenic variant, 12.8%). For the metastatic site, the proportion of peritoneal dissemination was significantly higher in BRCA1+ (71.9%) than BRCA− (55.1%) and not different from BRCA2+ (71.4%). With one of the most extensive patients, this study supported the previous reports showing that the pathogenic variants of BRCA1/2 were involved in the female genitalia’s disease sites.

本文言語English
論文番号36
ジャーナルWorld Journal of Surgical Oncology
19
1
DOI
出版ステータスPublished - 12-2021

All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学

フィンガープリント

「The disease sites of female genital cancers of BRCA1/2-associated hereditary breast and ovarian cancer: a retrospective study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル