The distribution of T lymphocytes, B lymphocytes, and dendritic-like cells of the anal tonsil in the laboratory shrew, Suncus murinus

Kazuyoshi Sakai, Genzoh Isomura, Masanori Shinzato, Hideki Imada, Keiki Yamada

研究成果: Article査読

抄録

We investigated the distribution of T lymphocytes, B lymphocytes, and S-100 protein-immunoreactive dendritic-like in the anal tonsil of the laboratory shrew, Suncus murinus. In adult animals, T lymphocytes were located mainly at the periphery of the anal tonsil, especially around small blood vessels. B lymphocytes were located in the central and subepithelial region of the anal tonsil, which includes primary lymphoid follicles, and in which there are small numbers of scattered T lymphocytes. B and T lymphocytes were distributed over 72.7 and 27.3% of the tonsillar area, respectively. However, their areas of distribution were not clearly distinguished. The areas containing B lymphocytes were enriched in S-100 protein antibody-immunoreactive cells, which exhibited a dendritic shape. These S-100-positive cells appeared to be identical to the follicular dendritic cells (FDC) seen in the follicles of lymphoid organs. These results suggest that the anal tonsils constitute one of the gut-associated lymphoid tissues (GALT), and that a function of the anal tonsil includes the capture of intruding antigens that would generate protective antibody responses.

本文言語English
ページ(範囲)819-824
ページ数6
ジャーナルMicroscopy Research and Technique
74
9
DOI
出版ステータスPublished - 09-2011

All Science Journal Classification (ASJC) codes

  • 解剖学
  • 組織学
  • 器械工学
  • 医療検査技術

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