The DNA sequence of human chromosome 22

I. Dunham, N. Shimizu, B. A. Roe, S. Chissoe, I. Dunham, A. R. Hunt, J. E. Collins, R. Bruskiewich, D. M. Beare, M. Clamp, L. J. Smink, R. Ainscough, J. P. Almeida, A. Babbage, C. Bagguley, J. Bailey, K. Barlow, K. N. Bates, O. Beasley, C. P. BirdS. Blakey, A. M. Bridgeman, D. Buck, J. Burgess, W. D. Burrill, J. Burton, C. Carder, N. P. Carter, Y. Chen, G. Clark, S. M. Clegg, V. Cobley, C. G. Cole, R. E. Collier, R. E. Connor, D. Conroy, N. Corby, G. J. Coville, A. V. Cox, J. Davis, E. Dawson, P. D. Dhami, C. Dockree, S. J. Dodsworth, R. M. Durbin, A. Ellington, K. L. Evans, J. M. Fey, K. Fleming, L. French, A. A. Garner, J. G.R. Gilbert, M. E. Goward, D. Grafham, M. N. Griffiths, C. Hall, R. Hall, G. Hall-Tamlyn, R. W. Heathcott, S. Ho, S. Holmes, S. E. Hunt, M. C. Jones, J. Kershaw, A. Kimberley, A. King, G. K. Laird, C. F. Langford, M. A. Leversha, C. Lloyd, D. M. Lloyd, I. D. Martyn, M. Mashreghi-Mohammadi, L. Matthews, O. T. Mccann, J. Mcclay, S. Mclaren, A. A. Mcmurray, S. A. Milne, B. J. Mortimore, C. N. Odell, R. Pavitt, A. V. Pearce, D. Pearson, B. J. Phillimore, S. H. Phillips, R. W. Plumb, H. Ramsay, Y. Ramsey, L. Rogers, M. T. Ross, C. E. Scott, H. K. Sehra, C. D. Skuce, S. Smalley, M. L. Smith, C. Soderlund, L. Spragon, C. A. Steward, J. E. Sulston, R. M. Swann, M. Vaudin, M. Wall, J. M. Wallis, M. N. Whiteley, D. Willey, L. Williams, S. Williams, H. Williamson, T. E. Wilmer, L. Wilming, C. L. Wright, T. Hubbard, D. R. Bentley, S. Beck, J. Rogers, N. Shimizu, S. Minoshima, K. Kawasaki, T. Sasaki, S. Asakawa, J. Kudoh, A. Shintani, K. Shibuya, Y. Yoshizaki, N. Aoki, S. Mitsuyama, B. A. Roe, F. Chen, L. Chu, J. Crabtree, S. Deschamps, A. Do, T. Do, A. Dorman, F. Fang, Y. Fu, P. Hu, A. Hua, S. Kenton, H. Lai, H. I. Lao, J. Lewis, S. Lewis, S. P. Lin, P. Loh, E. Malaj, T. Nguyen, H. Pan, S. Phan, S. Qi, Y. Qian, L. Ray, Q. Ren, S. Shaull, D. Sloan, L. Song, Q. Wang, Y. Wang, Z. Wang, J. White, D. Willingham, H. Wu, Z. Yao, M. Zhan, G. Zhang, S. Chissoe, J. Murray, N. Miller, P. Minx, R. Fulton, D. Johnson, G. Bemis, D. Bentley, H. Bradshaw, S. Bourne, M. Cordes, Z. Du, L. Fulton, D. Goela, T. Graves, J. Hawkins, K. Hinds, K. Kemp, P. Latreille, D. Layman, P. Ozersky, T. Rohlfing, P. Scheet, C. Walker, A. Wamsley, P. Wohldmann, K. Pepin, J. Nelson, I. Korf, J. A. Bedell, L. Hillier, E. Mardis, R. Waterston, R. Wilson, B. S. Emanuel, T. Shaikh, H. Kurahashi, S. Saitta, M. L. Budarf, H. E. Mcdermid, A. Johnson, A. C.C. Wong, B. E. Morrow, L. Edelmann, U. J. Kim, H. Shizuya, M. I. Simon, J. P. Dumanski, M. Peyrard, D. Kedra, E. Seroussi, I. Fransson, I. Tapia, C. E. Bruder, K. P. O'Brien

研究成果: Article査読

888 被引用数 (Scopus)

抄録

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.

本文言語English
ページ(範囲)489-495
ページ数7
ジャーナルNature
402
6761
DOI
出版ステータスPublished - 02-12-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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