The effect of ezetimibe on lipid and glucose metabolism after a fat and glucose load

Shinya Hiramitsu, Kenji Miyagishima, Junichi Ishii, Shigeru Matsui, Hiroyuki Naruse, Kenji Shiino, Fumihiko Kitagawa, Yukio Ozaki

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Objectives: The clinical benefit of ezetimibe, an intestinal cholesterol transporter inhibitor, for treatment of postprandial hyperlipidemia was assessed in subjects who ingested a high-fat and high-glucose test meal to mimic westernized diet. Methods: We enrolled 20 male volunteers who had at least one of the following: waist circumference ≥ 85cm, body mass index ≥ 25kg/m2, or triglycerides (TG) from 150 to 400mg/dL. After 4 weeks of treatment with ezetimibe (10mg/day), the subjects ingested a high-fat and high-glucose meal. Then changes in serum lipid and glucose levels were monitored after 0, 2, 4, and 6h, and the area under the curve (AUC) was calculated for the change in each parameter. Results and conclusion: At 4 and 6. h postprandially, TG levels were decreased (p<0.01) after 4 weeks of ezetimibe treatment, and the AUC for TG was also decreased (p<0.01). Apolipoprotein B48 (apo-B48) levels at 4 and 6. h postprandially were significantly decreased after ezetimibe treatment (p<0.01 and p<0.001, respectively), and the AUC for apo-B48 was also significantly decreased (p<0.01). Blood glucose and insulin levels at 2. h postprandially were significantly decreased by ezetimibe (p<0.05). The AUCs for blood glucose and insulin were also significantly decreased (p<0.05 and p<0.01, respectively). Since ezetimibe improved postprandial lipid and glucose metabolism, this drug is likely to be beneficial for dyslipidemia in patients with postprandial metabolic abnormalities.

本文言語English
ページ(範囲)395-400
ページ数6
ジャーナルJournal of cardiology
60
5
DOI
出版ステータスPublished - 11-2012

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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