The Effect of Lipopolysaccharide on the Disposition of Xanthines in Rats

Li Wang, Takaaki Hasegawa, Masayuki Nadai, Isao Muraoka, Toshitaka Nabeshima, Nobuo Kato

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Abstract— The effect of lipopolysaccharide (LPS) isolated from Klebsiella pneumoniae O3 on the pharmacokinetic behaviour and metabolism of the xanthines, theophylline and 1‐methyl‐3‐propylxanthine (MPX), which are mainly metabolized by the liver, was investigated in rats. LPS was infused at 0·25 mg kg−1 over a period of 20–30 min, 2 h before the administration of theophylline (10 mg kg−1) or MPX (2·5 mg kg−1). Concentrations of both xanthines in plasma and concentrations of the parent drug and metabolites in urine were measured by HPLC. Model‐independent methods were applied to estimate the pharmacokinetic parameters for both xanthines. No significant changes in the pharmacokinetic parameters or metabolism of theophylline were observed in rats pretreated with LPS. However, the total body clearance and volume of distribution of MPX were significantly increased by pretreatments with LPS. Significant decreases in the binding capacity and number of binding sites on the albumin molecule were observed in the presence of LPS. Changes occurring in the protein binding behaviour as a result of the introduction of LPS is a primary factor which not only increases the volume of distribution but also increases total body clearance. These results indicate that LPS has no effect on the pharmacokinetics and metabolic pathway of theophylline although it changes the disposition of MPX due to decreases in the extent of the protein binding of MPX which is highly bound to protein. 1993 Royal Pharmaceutical Society of Great Britain

本文言語English
ページ(範囲)34-38
ページ数5
ジャーナルJournal of Pharmacy and Pharmacology
45
1
DOI
出版ステータスPublished - 01-1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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