The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on stereotyped behavior in rats

M. Hiramatsu, T. Nabeshima, T. Kameyama, Y. Maeda, A. K. Cho

研究成果: Article査読

33 被引用数 (Scopus)

抄録

The relative potencies of S(+)-, R(-)-3,4-methylenedioxymethamphetamine (MDMA) and S(+)-methylenedioxyamphetamine (MDA) in inducing stereotyped behavior were determined in comparison with p-chloroamphetamine. S(+)-MDMA was more potent than R(-)-MDMA in eliciting stereotyped behaviors such as sniffing, head-weaving, backpedalling and turning and wet-dog-shakes. These results are consistent with the actions of the drug on release of neurotransmitters in which the S(+) enantiomer is more potent. The desmethyl derivative of (+)MDMA, (+)MDA, was more potent than (+)MDMA in eliciting stereotyped behaviors, and produced wet-dog shake behavior.

本文言語English
ページ(範囲)343-347
ページ数5
ジャーナルPharmacology, Biochemistry and Behavior
33
2
DOI
出版ステータスPublished - 06-1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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