The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice

Nozomi Endo, Manabu Makinodan, Takayo Mannari-Sasagawa, Noriko Horii-Hayashi, Nami Somayama, Takashi Komori, Toshifumi Kishimoto, Mayumi Nishi

研究成果: ジャーナルへの寄稿学術論文査読

14 被引用数 (Scopus)

抄録

Adverse experience in early life can affect the formation of neuronal circuits during postnatal development and exert long-lasting influences on neural functions that can lead to the development of a variety of psychiatric disorders including depression, anxiety disorders, and post-traumatic stress disorder. Many studies have demonstrated that daily repeated maternal separation, an animal model of early-life stress, can induce impairments in emotional behaviours and cognitive function during adolescence and adulthood. However, the behavioural phenotypes of maternally separated mice under long-term group-housing conditions are largely unknown. In this study, we applied our newly developed assay system to investigate the effects of maternal separation on behaviours under group-housing conditions during four days of continuous observations. Using our system, we found that repeated maternal separation resulted in inappropriate social distance from cagemates, altered approach preferences to others, and induced a lower rank in the time spent on the running wheel under group-housing conditions in adult male mice. Focussing on these behavioural abnormalities that appear in an environment with a social context will be important insights to understand the pathogenesis of psychiatric disorders.

本文言語英語
論文番号527
ジャーナルScientific reports
11
1
DOI
出版ステータス出版済み - 12-2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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