The effects of oral melatonin on the autonomic function in healthy subjects

Tsuyoshi Kitajima, Takashi Kanbayashi, Yasushi Saitoh, Yuriko Ogawa, Tomonari Sugiyama, Yoshihiko Kaneko, Yoshiko Sasaki, Rika Aizawa, Tetsuo Shimisu

研究成果: Article

32 引用 (Scopus)


We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.

ジャーナルPsychiatry and clinical neurosciences
出版物ステータスPublished - 07-07-2001


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


Kitajima, T., Kanbayashi, T., Saitoh, Y., Ogawa, Y., Sugiyama, T., Kaneko, Y., Sasaki, Y., Aizawa, R., & Shimisu, T. (2001). The effects of oral melatonin on the autonomic function in healthy subjects. Psychiatry and clinical neurosciences, 55(3), 299-300.