The effects of oral melatonin on the autonomic function in healthy subjects

Tsuyoshi Kitajima, Takashi Kanbayashi, Yasushi Saitoh, Yuriko Ogawa, Tomonari Sugiyama, Yoshihiko Kaneko, Yoshiko Sasaki, Rika Aizawa, Tetsuo Shimisu

研究成果: Article査読

33 被引用数 (Scopus)

抄録

We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.

本文言語English
ページ(範囲)299-300
ページ数2
ジャーナルPsychiatry and clinical neurosciences
55
3
DOI
出版ステータスPublished - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生

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