The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains

Hitoshi Niijima, Masataka Nagao, Makoto Nakajima, Takehiko Takatori, Mineo Iwasa, Yoshitaka Maeno, Hiroyoshi Koyama, Ichiro Isobe

研究成果: Article査読

11 被引用数 (Scopus)

抄録

One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents. (C) 2000 Elsevier Science Ireland Ltd.

本文言語English
ページ(範囲)171-178
ページ数8
ジャーナルForensic science international
112
2-3
DOI
出版ステータスPublished - 14-08-2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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