The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains

Hitoshi Niijima; Masataka Nagao; Makoto Nakajima; Takehiko Takatori; Mineo Iwasa; Yoshitaka Maeno; Hiroyoshi Koyama; Ichiro Isobe

doi:10.1016/S0379-0738(00)00274-7

The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains

Hitoshi Niijima, Masataka Nagao, Makoto Nakajima, Takehiko Takatori, Mineo Iwasa, Yoshitaka Maeno, Hiroyoshi Koyama, Ichiro Isobe

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

抄録

One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents. (C) 2000 Elsevier Science Ireland Ltd.

本文言語	英語
ページ（範囲）	171-178
ページ数	8
ジャーナル	Forensic science international
巻	112
号	2-3
DOI	https://doi.org/10.1016/S0379-0738(00)00274-7
出版ステータス	出版済み - 14-08-2000
外部発表	はい

All Science Journal Classification (ASJC) codes

病理学および法医学

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10.1016/S0379-0738(00)00274-7

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AU - Niijima, Hitoshi

AU - Nagao, Masataka

AU - Nakajima, Makoto

AU - Takatori, Takehiko

AU - Iwasa, Mineo

AU - Maeno, Yoshitaka

AU - Koyama, Hiroyoshi

AU - Isobe, Ichiro

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AB - One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents. (C) 2000 Elsevier Science Ireland Ltd.

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The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains

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