The effects of single and repeated phencyclidine administration on [125I] iomazenil binding in the rat brain

Koichi Kaneko, Akeo Kurumaji, Haruo Shibuya, Toshitaka Nabeshima, Michio Toru

研究成果: ジャーナルへの寄稿学術論文査読

5 被引用数 (Scopus)


We measured [125I] iomazenil binding, labeling the central-type benzodiazepine receptor in 37 discrete rat brain areas following single (7.5 mg/kg, i.p.) and repeated (7.5 mg/kg/day x 14 days, i.p.) treatment with phencyclidine (PCP), a non-competitive antagonist of the N-methyl-D-aspartate (NMDA)type glutamate receptor, using in vitro quantitative autoradiographic receptor binding assay. Both single and repeated PCP treatment produced heterogeneous changes in the rat brain in a similar manner, the magnitude of change in [125I] iomazenil binding being generally greater in the repeated treatment group than in the single treatment group. A significant increase in [125I] iomazenil binding was observed in the superficial layer (layer I-IV) of the parietal cortex in both of the PCP treatment groups and the CA1 of the hippocampus of the repeated PCP-treated group. There was a significant decrease in [125I] iomazenil binding in the piriform cortex of the repeated PCP-treated group. These results suggest that the blockade of NMDA receptor-mediated glutamatergic neurotransmission by PCP produces the compensational alterations in the central-type benzodiazepine receptor antagonist binding, and that the observed diversity may be due to dissimilar modes of organizations between glutamatergic and the GABA(γ-aminobutyric acid)-benzodiazepine receptor complex.

ジャーナルNeurochemistry International
出版ステータス出版済み - 09-1996

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 細胞生物学


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