The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes

Takahiro Watanabe; Yohei Narita; Masahiro Yoshida; Yoshitaka Sato; Fumi Goshima; Hiroshi Kimura; Takayuki Murata

doi:10.1128/JVI.01604-15

The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes

Takahiro Watanabe, Yohei Narita, Masahiro Yoshida, Yoshitaka Sato, Fumi Goshima, Hiroshi Kimura, Takayuki Murata

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

24 被引用数 (Scopus)

抄録

Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.

本文言語	英語
ページ（範囲）	10120-10124
ページ数	5
ジャーナル	Journal of Virology
巻	89
号	19
DOI	https://doi.org/10.1128/JVI.01604-15
出版ステータス	出版済み - 2015
外部発表	はい

All Science Journal Classification (ASJC) codes

微生物学
免疫学
昆虫科学
ウイルス学

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10.1128/JVI.01604-15

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title = "The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes",

abstract = "Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.",

author = "Takahiro Watanabe and Yohei Narita and Masahiro Yoshida and Yoshitaka Sato and Fumi Goshima and Hiroshi Kimura and Takayuki Murata",

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AU - Watanabe, Takahiro

AU - Narita, Yohei

AU - Yoshida, Masahiro

AU - Sato, Yoshitaka

AU - Goshima, Fumi

AU - Kimura, Hiroshi

AU - Murata, Takayuki

PY - 2015

Y1 - 2015

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AB - Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.

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The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes

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