The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population

Makiko Kishimoto, Hiroshi Ujike, Yuko Okahisa, Tatsuya Kotaka, Manabu Takaki, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Background: Frizzled 3 (Fzd3) is a receptor required for the Wnt-signaling pathway, which has been implicated in the development of the central nervous system, including synaptogenesis and structural plasticity. We previously found a significant association between the FZD3 gene and susceptibility to schizophrenia, but subsequent studies showed inconsistent findings. To understand the roles of the FZD3 gene in psychotic disorders further, it should be useful to examine FZD3 in patients with methamphetamine psychosis because the clinical features of methamphetamine psychosis are similar to those of schizophrenia. Methods: Six SNPs of FZD3, rs3757888 in the 3′ flanking region, rs960914 in the intron 3, rs2241802, a synonymous SNP in the exon5, rs232301 and rs352203 in the intron 5, and rs880481 in the intron 7, were selected based on the previous schizophrenic studies and analyzed in 188 patients with methamphetamine psychosis and 240 age- and gender-matched controls. Results: A case-control association analyses revealed that two kinds of FZD3 haplotypes showed strong associations with methamphetamine psychosis (p < 0.00001). Having the G-A-T-G or A-G-C-A haplotype of rs2241802-rs2323019-rs352203-rs880481 was a potent negative risk factor (odds ratios were 0.13 and 0.086, respectively) for methamphetamine psychosis. Conclusion: Our present and previous findings indicate that genetic variants of the FZD3 gene affect susceptibility to two analogous but distinct dopamine-related psychoses, endogenous and substance-induced psychosis.

本文言語English
論文番号37
ジャーナルBehavioral and Brain Functions
4
DOI
出版ステータスPublished - 15-08-2008

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Biological Psychiatry
  • Behavioral Neuroscience

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