The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder

Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Makiko Kishimoto, Yuko Okahisa, Tatsuya Kotaka, Mutsuo Harano, Toshiya Inada, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

研究成果: Article

21 引用 (Scopus)

抄録

Glycine transporter (GlyT)-1 plays a pivotal role in maintaining the glycine level at the glutamatergic synapse. Glycine is an allosteric agonist of N-methyl-D-aspartate (NMDA) receptors. Because activation of NMDA receptors is an essential step for induction of methamphetamine dependence and psychosis, differences in the functioning of GlyT-1 due to genetic variants of the GlyT-1 gene (GLYT1) may influence susceptibility. A case-control genetic association study of the GLYT1 gene examined 204 patients with methamphetamine-use disorder and 210 healthy controls. We examined three single nucleotide polymorphisms (SNPs), SNP1, IVS3 + 411C > T, rs2486001; SNP2, 1056G > A, rs2248829; and SNP3, IVS11 + 22G > A, rs2248632, of the GLYT1 gene and found that SNP1 showed a significant association in both genotype (P = 0.0086) and allele (P = 0.0019) with methamphetamine-use disorder. The T-G haplotype at SNP1 and SNP2 was a significant risk factor for the disorder (P = 0.000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis.

元の言語English
ページ(範囲)54-58
ページ数5
ジャーナルAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
147
発行部数1
DOI
出版物ステータスPublished - 05-01-2008

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Glycine Plasma Membrane Transport Proteins
Methamphetamine
Genes
N-Methyl-D-Aspartate Receptors
Psychotic Disorders
Glycine
Genetic Association Studies
Synapses
Haplotypes
Single Nucleotide Polymorphism
Alleles
Odds Ratio
Genotype

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

これを引用

Morita, Yukitaka ; Ujike, Hiroshi ; Tanaka, Yuji ; Kishimoto, Makiko ; Okahisa, Yuko ; Kotaka, Tatsuya ; Harano, Mutsuo ; Inada, Toshiya ; Komiyama, Tokutaro ; Hori, Toru ; Yamada, Mitsuhiko ; Sekine, Yoshimoto ; Iwata, Nakao ; Iyo, Masaomi ; Sora, Ichiro ; Ozaki, Norio ; Kuroda, Shigetoshi. / The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. :: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2008 ; 巻 147, 番号 1. pp. 54-58.
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abstract = "Glycine transporter (GlyT)-1 plays a pivotal role in maintaining the glycine level at the glutamatergic synapse. Glycine is an allosteric agonist of N-methyl-D-aspartate (NMDA) receptors. Because activation of NMDA receptors is an essential step for induction of methamphetamine dependence and psychosis, differences in the functioning of GlyT-1 due to genetic variants of the GlyT-1 gene (GLYT1) may influence susceptibility. A case-control genetic association study of the GLYT1 gene examined 204 patients with methamphetamine-use disorder and 210 healthy controls. We examined three single nucleotide polymorphisms (SNPs), SNP1, IVS3 + 411C > T, rs2486001; SNP2, 1056G > A, rs2248829; and SNP3, IVS11 + 22G > A, rs2248632, of the GLYT1 gene and found that SNP1 showed a significant association in both genotype (P = 0.0086) and allele (P = 0.0019) with methamphetamine-use disorder. The T-G haplotype at SNP1 and SNP2 was a significant risk factor for the disorder (P = 0.000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis.",
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Morita, Y, Ujike, H, Tanaka, Y, Kishimoto, M, Okahisa, Y, Kotaka, T, Harano, M, Inada, T, Komiyama, T, Hori, T, Yamada, M, Sekine, Y, Iwata, N, Iyo, M, Sora, I, Ozaki, N & Kuroda, S 2008, 'The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 巻. 147, 番号 1, pp. 54-58. https://doi.org/10.1002/ajmg.b.30565

The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. / Morita, Yukitaka; Ujike, Hiroshi; Tanaka, Yuji; Kishimoto, Makiko; Okahisa, Yuko; Kotaka, Tatsuya; Harano, Mutsuo; Inada, Toshiya; Komiyama, Tokutaro; Hori, Toru; Yamada, Mitsuhiko; Sekine, Yoshimoto; Iwata, Nakao; Iyo, Masaomi; Sora, Ichiro; Ozaki, Norio; Kuroda, Shigetoshi.

:: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 巻 147, 番号 1, 05.01.2008, p. 54-58.

研究成果: Article

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T1 - The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder

AU - Morita, Yukitaka

AU - Ujike, Hiroshi

AU - Tanaka, Yuji

AU - Kishimoto, Makiko

AU - Okahisa, Yuko

AU - Kotaka, Tatsuya

AU - Harano, Mutsuo

AU - Inada, Toshiya

AU - Komiyama, Tokutaro

AU - Hori, Toru

AU - Yamada, Mitsuhiko

AU - Sekine, Yoshimoto

AU - Iwata, Nakao

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Ozaki, Norio

AU - Kuroda, Shigetoshi

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N2 - Glycine transporter (GlyT)-1 plays a pivotal role in maintaining the glycine level at the glutamatergic synapse. Glycine is an allosteric agonist of N-methyl-D-aspartate (NMDA) receptors. Because activation of NMDA receptors is an essential step for induction of methamphetamine dependence and psychosis, differences in the functioning of GlyT-1 due to genetic variants of the GlyT-1 gene (GLYT1) may influence susceptibility. A case-control genetic association study of the GLYT1 gene examined 204 patients with methamphetamine-use disorder and 210 healthy controls. We examined three single nucleotide polymorphisms (SNPs), SNP1, IVS3 + 411C > T, rs2486001; SNP2, 1056G > A, rs2248829; and SNP3, IVS11 + 22G > A, rs2248632, of the GLYT1 gene and found that SNP1 showed a significant association in both genotype (P = 0.0086) and allele (P = 0.0019) with methamphetamine-use disorder. The T-G haplotype at SNP1 and SNP2 was a significant risk factor for the disorder (P = 0.000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis.

AB - Glycine transporter (GlyT)-1 plays a pivotal role in maintaining the glycine level at the glutamatergic synapse. Glycine is an allosteric agonist of N-methyl-D-aspartate (NMDA) receptors. Because activation of NMDA receptors is an essential step for induction of methamphetamine dependence and psychosis, differences in the functioning of GlyT-1 due to genetic variants of the GlyT-1 gene (GLYT1) may influence susceptibility. A case-control genetic association study of the GLYT1 gene examined 204 patients with methamphetamine-use disorder and 210 healthy controls. We examined three single nucleotide polymorphisms (SNPs), SNP1, IVS3 + 411C > T, rs2486001; SNP2, 1056G > A, rs2248829; and SNP3, IVS11 + 22G > A, rs2248632, of the GLYT1 gene and found that SNP1 showed a significant association in both genotype (P = 0.0086) and allele (P = 0.0019) with methamphetamine-use disorder. The T-G haplotype at SNP1 and SNP2 was a significant risk factor for the disorder (P = 0.000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis.

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