The hemolysis test of the Gyro C1E3 pump in pulsatile mode

Eiki Tayama, Tadashi Nakazawa, Yoshiyuki Takami, Kenzo Makinouchi, Satoshi Ohtsubo, Yukio Ohashi, Aron J.P. Andrade, Julie Glueck, Juergen Mueller, Yukihiko Nosé

研究成果: Article査読

26 被引用数 (Scopus)

抄録

While a centrifugal pump is generally used for nonpulsatile blood flow, it can also produce a pulsatile flow by alternating the impeller rotational speed (rpm) periodically. However, there is concern that this centrifugal pump pulsatile mode may induce added hemolysis as a result of the repeated acceleration and deceleration of rpm. Thus, a hemolysis study of the pulsatile modes of the Gym C1E3 centrifugal pump (Gyro-P) was conducted. The results were then compared with the nonpulsatile mode of the same Gyro pump (Gyro-N) and the nonpulsatile BioMedicus BP-80 (Bio-N) pump. Three different conditions were simulated: left ventricular assist device (LVAD), cardiopulmonary bypass (CPB), and percutaneous cardiopulmonary support (PCPS). The beating rate of the Gyro-P was set at 40 bpm, with repetition of 2 different impeller speeds (the lower rpm being 70% of the higher speed). The 2 impeller speeds were set to obtain the same average flow as that of the nonpulsatile mode. The hemolysis results of the Gyro-P were comparable to or better than those of the Bio-N, and no excessive hemolysis was observed, compared to the Gyro-N. In conclusion, the Gyro-P had an excellent hemolytic characteristic and generated no excessive hemolysis in most clinical usage conditions. With the concern of hemolysis eliminated, this pulsatile mode may have various possible advantages.

本文言語English
ページ(範囲)675-679
ページ数5
ジャーナルArtificial Organs
21
7
DOI
出版ステータスPublished - 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学

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