TY - JOUR
T1 - The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34
AU - Berger, Joel
AU - Kurahashi, Hiroki
AU - Takihara, Yoshihiro
AU - Shimada, Kazunori
AU - Brock, Hugh W.
AU - Randazzo, Filippo
N1 - Funding Information:
This research was supported by a grant from the Natural Sciences and Engineering Research Council and the Medical Research Council of Canada to H.W.B., by a Grant-in-Aid for International Scientific Research, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan to Y.T and K.S.
PY - 1999/9/3
Y1 - 1999/9/3
N2 - Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two l (3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.
AB - Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two l (3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.
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U2 - 10.1016/S0378-1119(99)00285-1
DO - 10.1016/S0378-1119(99)00285-1
M3 - Article
C2 - 10524249
AN - SCOPUS:0032839232
SN - 0378-1119
VL - 237
SP - 185
EP - 191
JO - Gene
JF - Gene
IS - 1
ER -