TY - JOUR
T1 - The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis
AU - Arisawa, Tomiyasu
AU - Tahara, Tomomitsu
AU - Shibata, Tomoyuki
AU - Nagasaka, Mitsuo
AU - Nakamura, Masakatsu
AU - Kamiya, Yoshio
AU - Fujita, Hiroshi
AU - Nakamura, Masahiko
AU - Yoshioka, Daisuke
AU - Arima, Yuko
AU - Okubo, Masaaki
AU - Hirata, Ichiro
AU - Nakano, Hiroshi
PY - 2008/1
Y1 - 2008/1
N2 - We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.
AB - We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.
KW - Interleukin-17 (IL-17)
KW - Single nucleotide polymorphism (SNP)
KW - Ulcerative colitis
UR - https://www.scopus.com/pages/publications/38149114618
UR - https://www.scopus.com/pages/publications/38149114618#tab=citedBy
U2 - 10.1007/s10875-007-9125-8
DO - 10.1007/s10875-007-9125-8
M3 - Article
C2 - 17828618
AN - SCOPUS:38149114618
SN - 0271-9142
VL - 28
SP - 44
EP - 49
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
IS - 1
ER -