The intensity of bronchiolar epithelial cell injury caused by an alloimmune response is ameliorated by transbronchial human interleukin-10 gene transfer in a rat model of lung transplantation

Hisashi Oishi, Yoshinori Okada, Toshiaki Kikuchi, Tetsu Sado, Masafumi Noda, Yasushi Hoshikawa, Akira Sakurada, Chiaki Endo, Takashi Kondo

研究成果: Article

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The aim of the present study was to determine whether the intensity of bronchiolar epithelial cell injury is ameliorated by transbronchial human IL-10 (hIL-10) gene transfer in a rat model of lung allograft rejection. The left lung was extracted from a donor Brown Norway rat and transbronchially instilled with encoding hIL-10 (IL-10 group) or β-galactosidase (control group). The lung graft was then transplanted into a Lewis rat and harvested on day 6 after transplantation. The allografts were histologically examined and all bronchioles in the slides were assigned one of three grades according to the intensity of epithelial cell loss. The distribution of the grades was significantly different between the two groups, and the epithelial cell injury was significantly improved in the IL-10 group. The present study demonstrated the effect of transbronchial hIL-10 gene transfer on ameliorating bronchiolar epithelial cell injury in a rat model of lung allograft rejection.

元の言語English
ページ(範囲)1458-1460
ページ数3
ジャーナルSurgery Today
41
発行部数10
DOI
出版物ステータスPublished - 10-2011

All Science Journal Classification (ASJC) codes

  • Surgery

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