The interaction of host genetic factors and Helicobacter pylori infection

T. Ando, Y. Goto, K. Ishiguro, O. Maeda, O. Watanabe, N. Ohmiya, Y. Niwa, N. Hamajima, E. El-Omar, H. Goto

研究成果: Review article

20 引用 (Scopus)

抄録

Helicobacter pylori plays an important role in the development of atrophic gastritis that represents the most recognized pathway in multistep gastric carcinogenesis. Recent studies suggest that a combination of host genetic factors, bacterial virulence factors, and environmental and lifestyle factors determine the severity of gastric damage and the eventual clinical outcome of Helicobacter pylori infection. As to bacterial virulence factors, a high proportion of Japanese strains are cagA+vacAs1. The CagA protein is injected from attached Helicobacter pylori into gastric epithelial cells and the CagA-SHP-2 interactions elicit cellular changes that increase the risk of carcinogenesis. Host cytokine gene polymorphisms and a frequent single nucleotide polymorphism in the PTPN11 gene that encodes SHP-2 may associate with gastric atrophy among Helicobacter pylori-infected subjects. Prevention of gastric cancer requires the development of better screening strategies for determining eradication candidates and further improvement of treatments of Helicobacter pylori infection.

元の言語English
ページ(範囲)10-14
ページ数5
ジャーナルInflammopharmacology
15
発行部数1
DOI
出版物ステータスPublished - 01-02-2007
外部発表Yes

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Helicobacter Infections
Helicobacter pylori
Stomach
Virulence Factors
Carcinogenesis
Atrophic Gastritis
Genes
Stomach Neoplasms
Atrophy
Single Nucleotide Polymorphism
Life Style
Epithelial Cells
Cytokines
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

これを引用

Ando, T., Goto, Y., Ishiguro, K., Maeda, O., Watanabe, O., Ohmiya, N., ... Goto, H. (2007). The interaction of host genetic factors and Helicobacter pylori infection. Inflammopharmacology, 15(1), 10-14. https://doi.org/10.1007/s10787-006-1556-y
Ando, T. ; Goto, Y. ; Ishiguro, K. ; Maeda, O. ; Watanabe, O. ; Ohmiya, N. ; Niwa, Y. ; Hamajima, N. ; El-Omar, E. ; Goto, H. / The interaction of host genetic factors and Helicobacter pylori infection. :: Inflammopharmacology. 2007 ; 巻 15, 番号 1. pp. 10-14.
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Ando, T, Goto, Y, Ishiguro, K, Maeda, O, Watanabe, O, Ohmiya, N, Niwa, Y, Hamajima, N, El-Omar, E & Goto, H 2007, 'The interaction of host genetic factors and Helicobacter pylori infection', Inflammopharmacology, 巻. 15, 番号 1, pp. 10-14. https://doi.org/10.1007/s10787-006-1556-y

The interaction of host genetic factors and Helicobacter pylori infection. / Ando, T.; Goto, Y.; Ishiguro, K.; Maeda, O.; Watanabe, O.; Ohmiya, N.; Niwa, Y.; Hamajima, N.; El-Omar, E.; Goto, H.

:: Inflammopharmacology, 巻 15, 番号 1, 01.02.2007, p. 10-14.

研究成果: Review article

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AU - Goto, Y.

AU - Ishiguro, K.

AU - Maeda, O.

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AU - Ohmiya, N.

AU - Niwa, Y.

AU - Hamajima, N.

AU - El-Omar, E.

AU - Goto, H.

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