The melanin-concentrating hormone system and its physiological functions

Yumiko Saito, Hiroshi Nagasaki

研究成果: Chapter

59 被引用数 (Scopus)

抄録

Melanin-concentrating hormone (MCH) is a neuropeptide that was originally isolated from salmon pituitary where it causes pigment aggregation. MCH is also abundantly present in mammalian neurons and expressed in the lateral hypothalamus and zona incerta, brain regions that are known to be at the center of feeding behavior. MCH binds to and activates two G protein-coupled receptors, MCH1R and MCH2R. Although MCH2R is non-functional in rodents, genetic and pharmacological studies have demonstrated that rodent MCH1R is involved in the regulation of feeding behavior and energy balance. Unexpectedly, some antagonists have provided evidence that MCH signaling participates in the regulation of other processes, such as emotion and stress. The discovery of MCH receptors has extensively promoted the progress of MCH studies and may represent an ideal example of how deorphanized receptors can open new directions toward more detailed physiological studies.

本文言語English
ホスト出版物のタイトルOrphan G Protein-Coupled Receptors and Novel Neuropeptides
編集者Olivier Civelli, Qun-Yong Zhou
ページ159-179
ページ数21
DOI
出版ステータスPublished - 2008
外部発表はい

出版物シリーズ

名前Results and Problems in Cell Differentiation
46
ISSN(印刷版)0080-1844
ISSN(電子版)1861-0412

All Science Journal Classification (ASJC) codes

  • 発生生物学
  • 細胞生物学

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