The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Ryouichi Banno, Hiroshi Arima, Ikuko Sato, Masayuki Hayashi, Motomitsu Goto, Yoshihisa Sugimura, Takashi Murase, Yutaka Oiso

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

本文言語English
ページ(範囲)1279-1286
ページ数8
ジャーナルPeptides
25
8
DOI
出版ステータスPublished - 01-08-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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