The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Ryouichi Banno; Hiroshi Arima; Ikuko Sato; Masayuki Hayashi; Motomitsu Goto; Yoshihisa Sugimura; Takashi Murase; Yutaka Oiso

doi:10.1016/j.peptides.2004.05.007

The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Ryouichi Banno, Hiroshi Arima, Ikuko Sato, Masayuki Hayashi, Motomitsu Goto, Yoshihisa Sugimura, Takashi Murase, Yutaka Oiso

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

抄録

Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

本文言語	英語
ページ（範囲）	1279-1286
ページ数	8
ジャーナル	Peptides
巻	25
号	8
DOI	https://doi.org/10.1016/j.peptides.2004.05.007
出版ステータス	出版済み - 08-2004
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
生理学
内分泌学
細胞および分子神経科学

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10.1016/j.peptides.2004.05.007

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title = "The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats",

abstract = "Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.",

author = "Ryouichi Banno and Hiroshi Arima and Ikuko Sato and Masayuki Hayashi and Motomitsu Goto and Yoshihisa Sugimura and Takashi Murase and Yutaka Oiso",

year = "2004",

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T1 - The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

AU - Banno, Ryouichi

AU - Arima, Hiroshi

AU - Sato, Ikuko

AU - Hayashi, Masayuki

AU - Goto, Motomitsu

AU - Sugimura, Yoshihisa

AU - Murase, Takashi

AU - Oiso, Yutaka

PY - 2004/8

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N2 - Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

AB - Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

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The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

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