The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects

Tsutomu Takahashi, Yumiko Nakamura, Yukako Nakamura, Branko Aleksic, Yoichiro Takayanagi, Atsushi Furuichi, Mikio Kido, Mihoko Nakamura, Daiki Sasabayashi, Masashi Ikeda, Kyo Noguchi, Kozo Kaibuchi, Nakao Iwata, Norio Ozaki, Michio Suzuki

研究成果: Article査読

11 被引用数 (Scopus)

抄録

An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p=0.004) and decreased Type I (p=0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p=0.005) and an increase in Type I (p=0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.

本文言語English
ページ(範囲)166-171
ページ数6
ジャーナルProgress in Neuro-Psychopharmacology and Biological Psychiatry
51
DOI
出版ステータスPublished - 03-06-2014

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 生物学的精神医学

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