The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation

H. Akamatsu, T. Horio

研究成果: Article査読

58 被引用数 (Scopus)

抄録

The purpose of this study was to investigate the possible role of reactive oxygen species (ROS) generated by neutrophils in mediating acne inflammation. Antibiotics used for the treatment of acne significantly inhibited ROS generated by neutrophils, when compared to other antibiotics. Metronidazole, which is effective in the treatment of acne, markedly inhibited ROS generated by neutrophils. The drug is known to have no significant effect on the growth of Propionibacterium acnes. The proportion of linoleic acid is markedly decreased in acne comedones. Linoleic acid significantly suppressed ROS generated by neutrophils. The ability of neutrophils to produce ROS was significantly increased in patients with acne inflammation. These results seem to reveal the involvement of ROS generated by neutrophils in the disruption of the integrity of the follicular epithelium, which is responsible for inflammatory processes of acne.

本文言語English
ページ(範囲)82-85
ページ数4
ジャーナルDermatology
196
1
DOI
出版ステータスPublished - 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 皮膚病学

フィンガープリント

「The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル