The presence of catechol-o-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells

M. Spatz, N. Kaneda, C. Sumi, I. Nagatsu, C. R. Creveling, T. Nagatsu

研究成果: Article査読

20 被引用数 (Scopus)

抄録

The activity of catechol-o-methyltransferase (COMT) was investigated in cultured and propagated cerebromicrovascular endothelial and smooth muscle cells using high performance liquid chromatography and immunocytochemistry. The existence of COMT was detected in both cell types. The demonstration of this enzyme activity in the cerebromicrovascular smooth muscle cells, in addition to the endothelium, indicates that the enzymatic barrier to catecholamine is not limited to capillaries, the main constituents of the blood-brain barrier.

本文言語English
ページ(範囲)363-367
ページ数5
ジャーナルBrain Research
381
2
DOI
出版ステータスPublished - 03-09-1986
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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