The presence of catechol-o-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells

M. Spatz, N. Kaneda, C. Sumi, I. Nagatsu, C. R. Creveling, T. Nagatsu

研究成果: Article

20 引用 (Scopus)

抄録

The activity of catechol-o-methyltransferase (COMT) was investigated in cultured and propagated cerebromicrovascular endothelial and smooth muscle cells using high performance liquid chromatography and immunocytochemistry. The existence of COMT was detected in both cell types. The demonstration of this enzyme activity in the cerebromicrovascular smooth muscle cells, in addition to the endothelium, indicates that the enzymatic barrier to catecholamine is not limited to capillaries, the main constituents of the blood-brain barrier.

元の言語English
ページ(範囲)363-367
ページ数5
ジャーナルBrain Research
381
発行部数2
DOI
出版物ステータスPublished - 03-09-1986

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Catechol O-Methyltransferase
Smooth Muscle Myocytes
Blood-Brain Barrier
Endothelium
Catecholamines
Immunohistochemistry
High Pressure Liquid Chromatography
Enzymes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

これを引用

Spatz, M. ; Kaneda, N. ; Sumi, C. ; Nagatsu, I. ; Creveling, C. R. ; Nagatsu, T. / The presence of catechol-o-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells. :: Brain Research. 1986 ; 巻 381, 番号 2. pp. 363-367.
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The presence of catechol-o-methyltransferase activity in separately cultured cerebromicrovascular endothelial and smooth muscle cells. / Spatz, M.; Kaneda, N.; Sumi, C.; Nagatsu, I.; Creveling, C. R.; Nagatsu, T.

:: Brain Research, 巻 381, 番号 2, 03.09.1986, p. 363-367.

研究成果: Article

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AU - Nagatsu, T.

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