抄録
Background/Aim: Peritumoral ectopic lymphoidlike structures and tertiary lymphoid structures (TLS), have been identified in various cancers. However, evidence for the role of TLS in endometrial cancer (EC) is lacking. We found a cluster of peritumoral lymphocytes with band-like structures (PLB) in the forefront of EC and analyzed their association with the clinical outcome. Materials and Methods: This was a single-center, retrospective cohort study. We evaluated peritumoral lymphoid cells using conventional hematoxylineosin and immunohistochemical staining by semi-quantitative digital analysis. Results: A total of 85 cases were included and the presence of PLB was examined. A strong correlation was observed between the density of PLB and progression-free survival (very low, low vs. intermediate, high; HR=0.22; 95%CI=0.093-0.52; p<0.001) and overall survival (very low, low vs. intermediate, high; HR=0.259; 95%CI=0.091-0.73; p=0.011). Conclusion: PLB in type II EC show a strong association with fatal outcome.
本文言語 | 英語 |
---|---|
ページ(範囲) | 249-258 |
ページ数 | 10 |
ジャーナル | Anticancer research |
巻 | 41 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 01-2021 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 腫瘍学
- 癌研究