The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

Yoshihiro Nakakubo; Yasuhiro Hida; Masaki Miyamoto; Hideaki Hashida; Taro Oshikiri; Kentaro Kato; Masato Suzuoki; Kei Hiraoka; Tomoo Ito; Toshiaki Morikawa; Shunichi Okushiba; Satoshi Kondo; Hiroyuki Katoh

doi:10.1016/S0304-3835(01)00773-X

The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

Yoshihiro Nakakubo
, Yasuhiro Hida
, Masaki Miyamoto
, Hideaki Hashida
, Taro Oshikiri
, Kentaro Kato
, Masato Suzuoki
, Kei Hiraoka
, Tomoo Ito
, Toshiaki Morikawa
, Shunichi Okushiba
, Satoshi Kondo
, Hiroyuki Katoh

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

40 被引用数 (Scopus)

抄録

Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.

本文言語	英語
ページ（範囲）	101-105
ページ数	5
ジャーナル	Cancer Letters
巻	177
号	1
DOI	https://doi.org/10.1016/S0304-3835(01)00773-X
出版ステータス	出版済み - 08-03-2002
外部発表	はい

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All Science Journal Classification (ASJC) codes

腫瘍学
癌研究

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10.1016/S0304-3835(01)00773-X

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title = "The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus",

abstract = "Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7\%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.",

author = "Yoshihiro Nakakubo and Yasuhiro Hida and Masaki Miyamoto and Hideaki Hashida and Taro Oshikiri and Kentaro Kato and Masato Suzuoki and Kei Hiraoka and Tomoo Ito and Toshiaki Morikawa and Shunichi Okushiba and Satoshi Kondo and Hiroyuki Katoh",

year = "2002",

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doi = "10.1016/S0304-3835(01)00773-X",

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T1 - The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

AU - Nakakubo, Yoshihiro

AU - Hida, Yasuhiro

AU - Miyamoto, Masaki

AU - Hashida, Hideaki

AU - Oshikiri, Taro

AU - Kato, Kentaro

AU - Suzuoki, Masato

AU - Hiraoka, Kei

AU - Ito, Tomoo

AU - Morikawa, Toshiaki

AU - Okushiba, Shunichi

AU - Kondo, Satoshi

AU - Katoh, Hiroyuki

PY - 2002/3/8

Y1 - 2002/3/8

N2 - Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.

AB - Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.

UR - https://www.scopus.com/pages/publications/18244388246

UR - https://www.scopus.com/pages/publications/18244388246#tab=citedBy

U2 - 10.1016/S0304-3835(01)00773-X

DO - 10.1016/S0304-3835(01)00773-X

M3 - Article

C2 - 11809537

AN - SCOPUS:18244388246

SN - 0304-3835

VL - 177

SP - 101

EP - 105

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

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