TY - JOUR
T1 - The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss)
AU - Dijkstra, Johannes Martinus
AU - Yoshiura, Yasutoshi
AU - Kiryu, Ikunari
AU - Aoyagi, Kazuhiko
AU - Köllner, Bernd
AU - Fischer, Uwe
AU - Nakanishi, Teruyuki
AU - Ototake, Mitsuru
PY - 2003/2
Y1 - 2003/2
N2 - In rainbow trout only a single classical major histocompatibility complex (MHC) class I locus has been identified. In previous studies it was shown that this locus, Onmy-UBA, is characterised by extensive polymorphism and ubiquitous expression. In the present study the sequence of the promoter region of Onmy-UBA was analysed. Within this region several fragments for transcription regulation could be detected, including interferon-sensitive enhancer elements. The promoter region is very similar to that of classical MHC class I in higher vertebrates. In agreement with the interferon sensitive elements identified in its promoter, Onmy-UBA expression in rainbow trout gonad cells (RTG-2 cell line) was up-regulated after infection with infectious haematopoietic necrosis virus (IHNV).
AB - In rainbow trout only a single classical major histocompatibility complex (MHC) class I locus has been identified. In previous studies it was shown that this locus, Onmy-UBA, is characterised by extensive polymorphism and ubiquitous expression. In the present study the sequence of the promoter region of Onmy-UBA was analysed. Within this region several fragments for transcription regulation could be detected, including interferon-sensitive enhancer elements. The promoter region is very similar to that of classical MHC class I in higher vertebrates. In agreement with the interferon sensitive elements identified in its promoter, Onmy-UBA expression in rainbow trout gonad cells (RTG-2 cell line) was up-regulated after infection with infectious haematopoietic necrosis virus (IHNV).
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U2 - 10.1006/fsim.2002.0431
DO - 10.1006/fsim.2002.0431
M3 - Article
C2 - 12526881
VL - 14
SP - 177
EP - 185
JO - Fish and Shellfish Immunology
JF - Fish and Shellfish Immunology
SN - 1050-4648
IS - 2
ER -