The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss)

Johannes Martinus Dijkstra, Yasutoshi Yoshiura, Ikunari Kiryu, Kazuhiko Aoyagi, Bernd Köllner, Uwe Fischer, Teruyuki Nakanishi, Mitsuru Ototake

    研究成果: ジャーナルへの寄稿学術論文査読

    24 被引用数 (Scopus)

    抄録

    In rainbow trout only a single classical major histocompatibility complex (MHC) class I locus has been identified. In previous studies it was shown that this locus, Onmy-UBA, is characterised by extensive polymorphism and ubiquitous expression. In the present study the sequence of the promoter region of Onmy-UBA was analysed. Within this region several fragments for transcription regulation could be detected, including interferon-sensitive enhancer elements. The promoter region is very similar to that of classical MHC class I in higher vertebrates. In agreement with the interferon sensitive elements identified in its promoter, Onmy-UBA expression in rainbow trout gonad cells (RTG-2 cell line) was up-regulated after infection with infectious haematopoietic necrosis virus (IHNV).

    本文言語英語
    ページ(範囲)177-185
    ページ数9
    ジャーナルFish and Shellfish Immunology
    14
    2
    DOI
    出版ステータス出版済み - 02-2003

    All Science Journal Classification (ASJC) codes

    • 環境化学
    • 水圏科学

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