The Relationship between Tryptophan Level in Serum and its Hepatic Uptake in Rats with Injured Liver by Carbon Tetrachloride

Morio Uemusa, Kuniaki Saito, Yoshiji Ohta, Isao Ishiguro, Madoka Ito, Yoichi Nagamura

研究成果: Article

1 引用 (Scopus)

抜粋

We have studied the relationship between the changes in tryptophan (free type and albumin bound type) in serum and its uptake in rat liver injured by i. p. administration of carbon tetrachloride. Total tryptophan concentration in serum remained high throughout the liver injury. Its high level was caused by elevation of free tryptophan resulting from a decrease In serum total protein, especially albumin, and a increase in free fatty acids. Hepatic uptake of tryptophan at high affininity sites (low Km) was impaired by liver injury, but that at low affinity ones (high Km) was not. A high level of tryptophan in serum should aid its hepatic uptake when the number of uptake sites on the liver cells surface is decreased because of liver injury.

元の言語English
ページ(範囲)147-153
ページ数7
ジャーナルJapanese Journal of Clinical Chemistry
17
発行部数4
DOI
出版物ステータスPublished - 01-01-1989

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

フィンガープリント The Relationship between Tryptophan Level in Serum and its Hepatic Uptake in Rats with Injured Liver by Carbon Tetrachloride' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用