The reversal effect of antidepressants on the escape deficit induced by inescapable shock in rats

Hideki Kametani, Soichiro Nomura, Jun Shimizu

研究成果: Article査読

33 被引用数 (Scopus)

抄録

This experiment investigated the effect of antidepressants on the escape deficit induced by inescapable shock. Following exposure te escapable shock, rats received a single injection of either tricyclic antidepressants (imipramine, desipramine), and atypical antidepressant (nomifensine), or saline. In a subsequent two-way shuttle test, treatments with these antidepressants reversed the escape deficit of the "inescapable-shock" groups without affecting performance of the "escapable-shock" groups. It is suggested that catecholamine re-uptake inhibition of the acute actions of antidepressants contributed to this reversal effect. The findings are discussed in relation to the neurochemical hypothesis of the escape deficit induced by inescapable shock and to an animal model of depression.

本文言語English
ページ(範囲)206-208
ページ数3
ジャーナルPsychopharmacology
80
3
DOI
出版ステータスPublished - 06-1983

All Science Journal Classification (ASJC) codes

  • 薬理学

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