The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA

Yuko Shimizu; Hironori Nishitsuji; Hiroyuki Marusawa; Saneyuki Ujino; Hiroshi Takaku; Kunitada Shimotohno

doi:10.1074/jbc.M114.563221

The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA

Yuko Shimizu
, Hironori Nishitsuji
, Hiroyuki Marusawa
, Saneyuki Ujino
, Hiroshi Takaku
, Kunitada Shimotohno

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

14 被引用数 (Scopus)

抄録

Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.

Significance: These data shed light on the selective regulation of APOBEC1 target genes.

Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.

Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.

本文言語	英語
ページ（範囲）	26226-26238
ページ数	13
ジャーナル	Journal of Biological Chemistry
巻	289
号	38
DOI	https://doi.org/10.1074/jbc.M114.563221
出版ステータス	出版済み - 19-09-2014
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
分子生物学
細胞生物学

文献へのアクセス

10.1074/jbc.M114.563221

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引用スタイル

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AU - Ujino, Saneyuki

AU - Takaku, Hiroshi

AU - Shimotohno, Kunitada

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