The roles of MAGE-D1 in the neuronal functions and pathology of the central nervous system

Akihiro Mouri, Yukihiro Noda, Ken Watanabe, Toshitaka Nabeshima

研究成果: Article

11 引用 (Scopus)

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Melanoma-associated antigen-D1 (MAGE-D1) was discovered in bone marrow stromal cells. MAGE-D1 is detected in progenitor cells in the neuroepithelia and subventricular regions as well as in the postmitotic neuronal cells in the entire brain in the developing embryo and is also detected in most adult tissues, predominantly in the brain. Herein, we provide an overview of the roles of MAGE-D1 in the central nervous system. MAGE-D1 participates in neurotrophin-induced neuronal differentiation and survival by modulating Trk-dependent phosphorylation. MAGE-D1 regulates Dlx-dependent migration-related transcription by binding to necdin or praja-1. MAGE-D1 regulates a number of apoptotic pathways, each caused by distinct input signals, such as bone morphogenetic protein, p75 neurotrophin receptor, and uncoordinated gene-5 homologue. MAGE-D1 knockout mice show depressive behavior and impairments of circadian rhythm caused by decreased ubiquitylation of serotonin transporter and regulated transcription of ROR α , respectively. The gene for necdin, a MAGE-D1-binding protein, has been described as responsible for Prader- Willi syndrome. In conclusion, MAGE-D1 plays important roles in the central nervous system in both developmental and adult stages and would be an invaluable target in the development of novel diagnostic and therapeutic agents for depression and Prader-Willi syndrome and also for providing new insights into the pathogenesis/ pathophysiology of these diseases.

元の言語English
ページ(範囲)61-70
ページ数10
ジャーナルReviews in the Neurosciences
24
発行部数1
DOI
出版物ステータスPublished - 01-02-2013
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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