TY - JOUR
T1 - The schizophrenia genetics knowledgebase
T2 - a comprehensive update of findings from candidate gene studies
AU - Liu, Chenxing
AU - Kanazawa, Tetsufumi
AU - Tian, Ye
AU - Mohamed Saini, Suriati
AU - Mancuso, Serafino
AU - Mostaid, Md Shaki
AU - Takahashi, Atsushi
AU - Zhang, Dai
AU - Zhang, Fuquan
AU - Yu, Hao
AU - Doo Shin, Hyoung
AU - Sub Cheong, Hyun
AU - Ikeda, Masashi
AU - Kubo, Michiaki
AU - Iwata, Nakao
AU - Woo, Sung Il
AU - Yue, Weihua
AU - Kamatani, Yoichiro
AU - Shi, Yongyong
AU - Li, Zhiqiang
AU - Everall, Ian
AU - Pantelis, Christos
AU - Bousman, Chad
N1 - Funding Information:
We express our gratitude to all of participants involved in the study. We acknowledge the SzGene study for their database of genetic association studies in schizophrenia. We would also like to acknowledge the Psychiatric GWAS Consortium (PGC) for making their valuable results publicly available. The Chinese GWAS set 1 was supported by grants from the National Key R&D Program of China (2016YFC1307000), the National Natural Science Foundation of China (91432304, 81571313). The Chinese GWAS set 2 was supported by grants from the 973 Program (2015CB559100), the National Key R&D Program of China (2016YFC0903402), the Natural Science Foundation of China (31325014, 81421061, 81130022, 81701321, 31770800 and 81571329), the Program of Shanghai Subject Chief Scientist (15XD1502200), the National Program for Support of Top-Notch Young Professionals to Y.S., the ‘Shu Guang’ project supported by the Shanghai Municipal Education Commission and Shanghai Education Development Foundation (12SG17 to Y.S.). The Chinese GWAS set 3 was supported by grants from the Primary Research & Development Plan of Jiangsu Province (BE2016630). The Korean GWAS set was supported by grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea (no. A101023). C.P. was supported by a NHMRC Senior Principal Research Fellowship (1105825). C.B. was supported by the Alberta Children’s Research Institute and Cumming School of Medicine, University of Calgary.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies’ findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.
AB - Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies’ findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.
UR - http://www.scopus.com/inward/record.url?scp=85071309317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071309317&partnerID=8YFLogxK
U2 - 10.1038/s41398-019-0532-4
DO - 10.1038/s41398-019-0532-4
M3 - Article
C2 - 31455759
AN - SCOPUS:85071309317
SN - 2158-3188
VL - 9
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 205
ER -