The serum pepsinogen test as a predictor of gastric cancer: The Hisayama study

Yoshinori Oishi, Yutaka Kiyohara, Michiaki Kubo, Keiichi Tanaka, Yumihiro Tanizaki, Toshiharu Ninomiya, Yasufumi Doi, Kentaro Shikata, Koji Yonemoto, Tomoko Shirota, Takayuki Matsumoto, Mitsuo Iida

研究成果: Article

92 引用 (Scopus)

抄録

The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged ≥40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n = 17; age-adjusted hazard ratio = 4.56, 95% confidence interval: 2.42, 8.60) and women (n = 6; age-adjusted hazard ratio = 5.84, 95% confidence interval: 2.00, 17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n = 23; age-adjusted hazard ratio = 3.91, 95% confidence interval: 2.23, 6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori-negative and -positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection.

元の言語English
ページ(範囲)629-637
ページ数9
ジャーナルAmerican Journal of Epidemiology
163
発行部数7
DOI
出版物ステータスPublished - 01-04-2006

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Pepsinogen A
Stomach Neoplasms
Serum
Intestinal Neoplasms
Confidence Intervals
Helicobacter pylori
Pepsinogen C
Helicobacter Infections

All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Oishi, Y., Kiyohara, Y., Kubo, M., Tanaka, K., Tanizaki, Y., Ninomiya, T., ... Iida, M. (2006). The serum pepsinogen test as a predictor of gastric cancer: The Hisayama study. American Journal of Epidemiology, 163(7), 629-637. https://doi.org/10.1093/aje/kwj088
Oishi, Yoshinori ; Kiyohara, Yutaka ; Kubo, Michiaki ; Tanaka, Keiichi ; Tanizaki, Yumihiro ; Ninomiya, Toshiharu ; Doi, Yasufumi ; Shikata, Kentaro ; Yonemoto, Koji ; Shirota, Tomoko ; Matsumoto, Takayuki ; Iida, Mitsuo. / The serum pepsinogen test as a predictor of gastric cancer : The Hisayama study. :: American Journal of Epidemiology. 2006 ; 巻 163, 番号 7. pp. 629-637.
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abstract = "The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged ≥40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n = 17; age-adjusted hazard ratio = 4.56, 95{\%} confidence interval: 2.42, 8.60) and women (n = 6; age-adjusted hazard ratio = 5.84, 95{\%} confidence interval: 2.00, 17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n = 23; age-adjusted hazard ratio = 3.91, 95{\%} confidence interval: 2.23, 6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori-negative and -positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection.",
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Oishi, Y, Kiyohara, Y, Kubo, M, Tanaka, K, Tanizaki, Y, Ninomiya, T, Doi, Y, Shikata, K, Yonemoto, K, Shirota, T, Matsumoto, T & Iida, M 2006, 'The serum pepsinogen test as a predictor of gastric cancer: The Hisayama study', American Journal of Epidemiology, 巻. 163, 番号 7, pp. 629-637. https://doi.org/10.1093/aje/kwj088

The serum pepsinogen test as a predictor of gastric cancer : The Hisayama study. / Oishi, Yoshinori; Kiyohara, Yutaka; Kubo, Michiaki; Tanaka, Keiichi; Tanizaki, Yumihiro; Ninomiya, Toshiharu; Doi, Yasufumi; Shikata, Kentaro; Yonemoto, Koji; Shirota, Tomoko; Matsumoto, Takayuki; Iida, Mitsuo.

:: American Journal of Epidemiology, 巻 163, 番号 7, 01.04.2006, p. 629-637.

研究成果: Article

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T1 - The serum pepsinogen test as a predictor of gastric cancer

T2 - The Hisayama study

AU - Oishi, Yoshinori

AU - Kiyohara, Yutaka

AU - Kubo, Michiaki

AU - Tanaka, Keiichi

AU - Tanizaki, Yumihiro

AU - Ninomiya, Toshiharu

AU - Doi, Yasufumi

AU - Shikata, Kentaro

AU - Yonemoto, Koji

AU - Shirota, Tomoko

AU - Matsumoto, Takayuki

AU - Iida, Mitsuo

PY - 2006/4/1

Y1 - 2006/4/1

N2 - The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged ≥40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n = 17; age-adjusted hazard ratio = 4.56, 95% confidence interval: 2.42, 8.60) and women (n = 6; age-adjusted hazard ratio = 5.84, 95% confidence interval: 2.00, 17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n = 23; age-adjusted hazard ratio = 3.91, 95% confidence interval: 2.23, 6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori-negative and -positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection.

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