The sex differences of cerebrospinal fluid levels of interleukin 8 and antioxidants in asphyxiated newborns

Mohamed Hamed Hussein, Ghada A. Daoud, Hiroki Kakita, Ayako Hattori, Hiroki Murai, Mari Yasuda, Keisuke Mizuno, Kenji Goto, Yasuhiko Ozaki, Tetsuya Ito, Taihei Tanaka, Sumio Fukuda, Ineko Kato, Shinji Fujimoto, Satoshi Suzuki, Hisanori Sobajima, Hajime Togari

研究成果: Article

16 引用 (Scopus)

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Newborn males are more sensitive to brain injury than newborn females are. The aim of the present study was to find an explanation for this. We used the neuron-specific enolase (NSE) levels in the cerebrospinal fluid (CSF) for the classification of 32 newborns (19 males and 13 females) on their fifth postnatal day. The NSE levels were higher than normal (8.4 ± 1.6 ng/mL) in 10 newborn males and 6 females and were, respectively, considered asphyxiated male and female groups. The remaining newborns, 9 males and 7 females, had normal CSF levels of NSE and were considered normal newborn male and female groups. The CSF samples were measured for 12 cytokines, using a cytokine array kit, and for total hydroperoxide and biological antioxidant potentials (BAPs), using the free radical analytic system. Among the 12 cytokines measured, only interleukin 8 (IL-8) was properly detected. The CSF levels of IL-8 were higher in the asphyxiated newborn females than in the other three groups. The mean CSF levels of BAPs in the asphyxiated newborn females were higher compared with the other three groups, but significance was detected only in comparison with the BAP levels in the CSF samples of the normal newborn males. There were no differences in total hydroperoxide levels among the groups. There are sex-related differences in the CSF levels of IL-8 and antioxidants in asphyxiated newborns, with higher levels in newborn females; this might contribute in the sexual dimorphism regarding the fact that females have better protection from brain injury than the males.

元の言語English
ページ(範囲)154-159
ページ数6
ジャーナルShock
28
発行部数2
DOI
出版物ステータスPublished - 01-08-2007
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

フィンガープリント The sex differences of cerebrospinal fluid levels of interleukin 8 and antioxidants in asphyxiated newborns' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Hussein, M. H., Daoud, G. A., Kakita, H., Hattori, A., Murai, H., Yasuda, M., Mizuno, K., Goto, K., Ozaki, Y., Ito, T., Tanaka, T., Fukuda, S., Kato, I., Fujimoto, S., Suzuki, S., Sobajima, H., & Togari, H. (2007). The sex differences of cerebrospinal fluid levels of interleukin 8 and antioxidants in asphyxiated newborns. Shock, 28(2), 154-159. https://doi.org/10.1097/shk.0b013e31803dcf55