The therapeutic effect of Lipo PGE1 on diabetic neuropathy-changes in endothelin and various angiopathic factors

Yasutoshi Itoh, Tadashi Yasui, Hiroaki Kakizawa, Masaki Makino, Kentaro Fujiwara, Taiya Kato, Shigeo Imamura, Keiko Yamamoto, Hitoshi Hishida, Akira Nakai, Mitusyasu Itoh, Akio Nagasaka

研究成果: Article査読

17 被引用数 (Scopus)

抄録

A high blood concentration of endothelin (ET)-1 may participate in the onset and progress of diabetic microangiopathy, resulting in neuropathy. We examined the therapeutic effects of prostaglandin E1 (PGE1), which possesses both a peripheral vasodilating action and inhibition of platelet aggregation, on diabetic microangiopathy. Increases in both skin temperature and peripheral never conduction velocity in diabetic patients were recorded four weeks after Lipo PGE1 administration. A quantitative decrease in urinary albumin concentration was also observed, suggesting its efficacy of action was on diabetic nephropathy. Lipo PGE1 administration reduced the elevated circulating plasma ET-1 levels in the diabetic patients. As an increase in ET-1 concentrations is thought to correlate with the onset and progress of diabetic microangiopathy, the reduction of plasma ET-1 concentration by Lipo PGE1 administration may be one reason for the improvement in diabetic neuropathy and nephropathy.

本文言語English
ページ(範囲)221-234
ページ数14
ジャーナルProstaglandins and Other Lipid Mediators
66
3
DOI
出版ステータスPublished - 2001

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 薬理学
  • 細胞生物学

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