The therapeutic effects of the herbal medicine, Juzen-taiho-to, on amyloid-β burden in a mouse model of alzheimer's disease

Hideo Hara, Seiko Kataoka, Mayumi Anan, Akihiro Ueda, Tatsuro Mutoh, Takeshi Tabira

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Innate immunity, especially that involving macrophage function, reportedly diminishes with advancing age and in patients with Alzheimer's disease (AD). In this study, we tried to elicit the non-specific activation of peripheral macrophages by oral administration of the herbal medicine Juzen-taiho-to (JTT), to assess its effect as a possible treatment for AD patients. Amyloid-β protein precursor transgenic mice were used as a model of AD to clarify the effect of JTT. Activated macrophages derived from bone marrow cross the blood-brain barrier, and then develop into microglia, which phagocytose aggregated amyloid-β (Aβ) in senile plaques. Here we show that orally administered JTT increased the number of CD11b-positive ramified microglia in the mouse brain. The immunohistochemical examination of brain sections stained with polyclonal anti-Aβ antibody showed reduced Aβ burden, and Aβ levels were also decreased in the insoluble fractions of brain homogenates, as determined by ELISA. Thus, the activation of peripheral macrophages by JTT might be a potential new therapeutic strategy for AD.

本文言語English
ページ(範囲)427-439
ページ数13
ジャーナルJournal of Alzheimer's Disease
20
2
DOI
出版ステータスPublished - 2010

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 臨床心理学
  • 老年医学
  • 精神医学および精神衛生

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