The US11 gene product of herpes simplex virus has intercellular trafficking activity

Tetsuo Koshizuka, Hiroki Takakuwa, Fumi Goshima, Takayuki Murata, Yukihiro Nishiyama

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The US11 gene product of herpes simplex virus is an abundant virion structural protein with RNA-binding regulatory activity. Its carboxyl-terminal half consists of tandem tripeptide repeats of the sequence RXP. We demonstrate that the US11 protein has intercellular trafficking activity and accumulates in the nucleolus when singly expressed in cultured cells, and that the RXP repeats are responsible for this activity. These same properties were also observed in cells expressing a fusion protein linking US11 to the green fluorescent protein. Furthermore, exogenous US11 protein was internalized by cells at 4°C, which suggests that US11 protein uptake occurs primarily through an energy-independent pathway.

本文言語English
ページ(範囲)597-602
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
288
3
DOI
出版ステータスPublished - 02-11-2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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