The US3 protein kinase of herpes simplex virus attenuates the activation of the c-Jun N-terminal protein kinase signal transduction pathway in infected piriform cortex neurons of C57BL/6 mice

Isamu Mori, Fumi Goshima, Tetsuo Koshizuka, Naoki Koide, Tsuyoshi Sugiyama, Tomoaki Yoshida, Takashi Yokochi, Yoshinobu Kimura, Yukihiro Nishiyama

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Stereotaxic microinjection of herpes simplex virus (HSV) into the mouse olfactory bulb resulted in infection of neurons of the piriform cortex. Neurons infected with the wildtype HSV showed no evident phosphorylation of c-Jun N-terminal protein kinase (JNK)/c-Jun. In contrast, neurons infected with a US3 gene-disrupted mutant of the L1BR1 virus displayed phosphorylated JNK/c-Jun in a nuclear staining fashion. Induction of neuronal apoptosis by the wildtype HSV was partially suppressed when compared with that of the L1BR1 virus. A US3-rescued isolate of the L1B-11 virus behaved as did the wildtype virus. Collectively, the US3 protein kinase of HSV plays a role in attenuating the virus-induced activation of the JNK signal transduction pathway in the central nervous system and may contribute, at least in part, to controlling neuronal apoptosis.

本文言語English
ページ(範囲)201-205
ページ数5
ジャーナルNeuroscience Letters
351
3
DOI
出版ステータスPublished - 20-11-2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

フィンガープリント 「The US3 protein kinase of herpes simplex virus attenuates the activation of the c-Jun N-terminal protein kinase signal transduction pathway in infected piriform cortex neurons of C57BL/6 mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル