@article{a41345956bee4e52945013a8ee9c46fe,
title = "The US3 protein kinase of herpes simplex virus attenuates the activation of the c-Jun N-terminal protein kinase signal transduction pathway in infected piriform cortex neurons of C57BL/6 mice",
abstract = "Stereotaxic microinjection of herpes simplex virus (HSV) into the mouse olfactory bulb resulted in infection of neurons of the piriform cortex. Neurons infected with the wildtype HSV showed no evident phosphorylation of c-Jun N-terminal protein kinase (JNK)/c-Jun. In contrast, neurons infected with a US3 gene-disrupted mutant of the L1BR1 virus displayed phosphorylated JNK/c-Jun in a nuclear staining fashion. Induction of neuronal apoptosis by the wildtype HSV was partially suppressed when compared with that of the L1BR1 virus. A US3-rescued isolate of the L1B-11 virus behaved as did the wildtype virus. Collectively, the US3 protein kinase of HSV plays a role in attenuating the virus-induced activation of the JNK signal transduction pathway in the central nervous system and may contribute, at least in part, to controlling neuronal apoptosis.",
keywords = "Apoptosis, Herpes simplex virus, Oxidative stress, Piriform cortex, US3 protein kinase, c-Jun N-terminal protein kinase, p38 mitogen-activated protein kinase",
author = "Isamu Mori and Fumi Goshima and Tetsuo Koshizuka and Naoki Koide and Tsuyoshi Sugiyama and Tomoaki Yoshida and Takashi Yokochi and Yoshinobu Kimura and Yukihiro Nishiyama",
note = "Funding Information: We would like to thank E. Iwata and T. Tsuruguchi for technical assistance. This work was supported in part by a grant from The Waksman Foundation of Japan and JSPS KAKENHI (15590424). Isamu Mori was the recipient of an Encouragement of Young Scientist Award from the Nakanihon Infectious Diseases Research Foundation, Japan.",
year = "2003",
month = nov,
day = "20",
doi = "10.1016/j.neulet.2003.08.033",
language = "English",
volume = "351",
pages = "201--205",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}