Thrombotic thrombocytopenic purpura achieving complete remission by slow infusion of vincristine

K. Yokoyama, M. Kojima, S. Komatsumoto, M. Nara, M. Nakano, Y. Ikeda, K. Toyama

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A case of thrombotic thrombocytopenic purpura (TTP) which was successfully treated by slow infusion of vincristine (VCR) is reported. A 40-year-old female was admitted to our hospital because of sudden onset of genital bleeding. Her blood cell count showed severe anemia and thrombocytopenia. Biochemistry disclosed high titers of serum LDH. Based upon these findings, the patient was initially diagnosed as having Evans syndrome and was treated with steroid-pulse therapy and high-dose immunoglobulin. However, no response was obtained. A diagnosis of TTP was established when mental disturbance and renal dysfunction developed later. Aspirin and plasmapheresis relieved the mental disturbance and decreased serum LDH level, but anemia and thrombocytopenia were not corrected. Slow infusion therapy of 1 to 2 mg VCR was performed for 4 to 8 hours once a week, which dramatically improved the hematological abnormalities and controlled the disease. In conclusion, slow infusion of VCR may indicated, if initial standard therapies such as PE would fail.

本文言語English
ページ(範囲)1084-1089
ページ数6
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
33
8
出版ステータスPublished - 08-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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