Thyroid size change by CT monitoring after sorafenib or sunitinib treatment in patients with renal cell carcinoma: Comparison with thyroid function

Kazuhiro Kitajima, Satoru Takahashi, Tetsuo Maeda, Takeshi Yoshikawa, Yoshiharu Ohno, Masahiko Fujii, Hideaki Miyake, Masato Fujisawa, Kazuro Sugimura

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Objective: Hypothyroidism is a common complication in patients receiving tyrosine kinase inhibitors. We evaluated the relationship between thyroid size evident on CT and thyroid function in patients with advanced renal cell carcinoma (RCC) receiving tyrosine kinase inhibitors. Materials and methods: Forty-two patients with metastatic RCC receiving tyrosine kinase inhibitors (sorafenib n = 25; sunitinib n = 17) and, followed-up for ≥12 months were eligible. Patients who had ever shown an elevated thyroid-stimulating hormone (TSH) level of >10 mU/l were defined as having "hypothyroidism". CT scans were performed before, and 3, 6, 9, and 12 months after the start of treatment. The area of the thyroid in the maximum section at each examination was measured and compared with that before treatment. Using repeated-measures ANOVA, differences in thyroid size were compared over time between patients with and without "hypothyroidism", in relation to the type of drug employed. Results: Twenty-one patients (sorafenib 9, sunitinib 12) developed "hypothyroidism" 95 ± 88 days (range 12-315 days) after the start of treatment. In such patients, the thyroid was reduced in size to 89 ± 16% after 3 months, 81 ± 21% after 6 months, 71 ± 21% after 9 months and 68 ± 21% after 12 months, whereas the patients without "hypothyroidism" maintained a thyroid size of 90 ± 12% even after 12 months (p = 0.0030). Among the patients with "hypothyroidism" , those treated with sunitinib tended to show greater thyroid size reduction than those with sorafenib (59 ± 23% vs. 79 ± 13%, after 12 months). Conclusion: Tyrosine kinase inhibitors cause an apparent thyroid size reduction in patients with "hypothyroidism".

本文言語English
ページ(範囲)2060-2065
ページ数6
ジャーナルEuropean journal of radiology
81
9
DOI
出版ステータスPublished - 09-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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