Tight junctions in Schwann cells of peripheral myelinated axons: A lesson from claudin-19-deficient mice

Tatsuo Miyamoto, Kazumasa Morita, Daisuke Takemoto, Kosei Takeuchi, Yuka Kitano, Tsuyoshi Miyakawa, Kiyomi Nakayama, Yasushi Okamura, Hiroyuki Sasaki, Yoshiki Miyachi, Mikio Furuse, Shoichiro Tsukita

研究成果: Article

130 引用 (Scopus)

抜粋

Tight junction (TJ)-like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. Claudin-19-deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peripheral nervous system deficits. Electrophysiological analyses showed that the claudin-19 deficiency affected the nerve conduction of peripheral myelinated fibers. Interestingly, the overall morphology of Schwann cells lacking claudin-19 expression appeared to be normal not only in the internodal region but also at the node of Ranvier, except that TJs completely disappeared, at least from the outer/inner mesaxons. These findings have indicated that, similar to epithelial cells, Schwann cells also bear claudin-based TJs, and they have also suggested that these TJs are not involved in the polarized morphogenesis but are involved in the electrophysiological "sealing" function of Schwann cells.

元の言語English
ページ(範囲)527-538
ページ数12
ジャーナルJournal of Cell Biology
169
発行部数3
DOI
出版物ステータスPublished - 09-05-2005

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Cell Biology

これを引用

Miyamoto, T., Morita, K., Takemoto, D., Takeuchi, K., Kitano, Y., Miyakawa, T., Nakayama, K., Okamura, Y., Sasaki, H., Miyachi, Y., Furuse, M., & Tsukita, S. (2005). Tight junctions in Schwann cells of peripheral myelinated axons: A lesson from claudin-19-deficient mice. Journal of Cell Biology, 169(3), 527-538. https://doi.org/10.1083/jcb.200501154