Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity

Ayumi Fukakusa, Hiroyuki Mizoguchi, Hiroyuki Koike, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

研究成果: Article査読

1 被引用数 (Scopus)

抄録

To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA-/-), and protease activated receptor-1-deficient (PAR-1-/-) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.

本文言語English
ページ(範囲)321-324
ページ数4
ジャーナルJournal of Pharmacological Sciences
106
2
DOI
出版ステータスPublished - 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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