TNF-α and IL-6 signals from the bone marrow derived cells are necessary for normal murine liver regeneration

Kaori Sudo, Yasuhiro Yamada, Kuniaki Saito, Syogo Shimizu, Hazuki Ohashi, Tomohiro Kato, Hisataka Moriwaki, Hiroyasu Ito, Mitsuru Seishima

研究成果: Article査読

30 被引用数 (Scopus)

抄録

In the present study, we used bone marrow transplanted mice and revealed the role of bone marrow derived cells in liver regeneration after partial hepatectomy (PH). Irradiated wild type (WT) mice received a bone marrow transplant from either WT, TNF (tumor necrosis factor)-α knockout (KO), or interleukin (IL)-6 KO donors. Both TNF-α KO- and IL-6 KO-transplanted mice compared with WT-transplanted mice showed decreased hepatocyte DNA synthesis after PH. TNF-α KO-transplanted mice showed no nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription (STAT) 3 binding after PH, while IL-6 KO-transplanted mice showed NF-κB, but not STAT3, binding. Lack of AP-1 or C/EBP binding or expression of c-jun or c-myc mRNA after PH was unrelated to the timing and amount of DNA replication. In conclusion, The TNF-α and IL-6 signals from the blood are necessary for liver regeneration and NF-κB and STAT3 binding are activated via TNF-α and IL-6 signal pathways.

本文言語English
ページ(範囲)671-679
ページ数9
ジャーナルBiochimica et Biophysica Acta - Molecular Basis of Disease
1782
11
DOI
出版ステータスPublished - 11-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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